Against eternal rivals "Barcelona" team will have to play without their leader Lionel Messi.
The publication "Sport" announced that the Argentinean, who is healing from a knee injury, did not confirm optimistic forecasts and will have to miss the match against Madrid "Real".
Due to the injury, Messi was not included in the Argentina national team squad for matches against Brazil and Colombia.
It is stated that the superstar's rehabilitation could take another four weeks, as he is still unable to perform running exercises.
The first season's "El Clasico" match will be played on November 21 at the "Santiago Bernabeu" stadium.