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Wayne Rooney will miss Wednesday's Champions League match against Valencia due to injury.
One of the leaders injured his thigh in the Premier League match against Bolton, which ended in a 2-2 draw on Sunday.
However, Rooney, embroiled in a scandal involving sex with a prostitute, has not yet found his form this season and has only scored one goal - a penalty against West Ham in London a month ago.
Manchester United manager Sir Alex Ferguson recently admitted that the Englishman is struggling to cope with increased pressure from the media and surroundings.
Rooney's performances from last season were much more successful: