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Jesus Navas may be forced to finish the season without the right winger, who suffered a leg injury.
Medical tests revealed that the footballer will be out of the lineup for four to six weeks.
According to the club, this practically means that the Spaniard will not be able to take the field for the rest of the season.
With seven games left until the end of the season, Sevilla is in fifth place in the Spanish championship with 46 points.