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Until the end of this season, Dortmund will have to cope without attacking midfielder Nuri Sahin, who suffered a ligament injury.
The 22-year-old Turkish national team player has shown impressive athletic form this season, but will miss the remaining four matches.
It is reported that Sahin, who has been linked with a move to Real Madrid, will be out of action for six weeks.
Borussia is currently leading the German league and is eight points ahead of its closest pursuers. If the team wins the next match and Leverkusen's Bayer drops points, Dortmund will secure the national championship title.
