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During the first Champions League semi-final match on Tuesday in Gelsenkirchen, they will have to do without the most productive football player Dimitar Berbatov.
The Bulgarian, who has been entering the starting lineup less frequently lately, has suffered a groin injury.
This season, Berbatov has scored 22 goals, but the effective duo of Wayne Rooney and Javier Hernandez earned greater trust from coach Sir Alex Ferguson in the second half of the season.
Darren Fletcher, who has health problems, did not travel to Gelsenkirchen either.