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Rio Ferdinand will miss the first Champions League match against Lisbon's "Benfica".
The center-back, who recently recovered from an injury, was given a rest as he played the full 90 minutes on Saturday.
Another main center-back Nemanja Vidic will also not play, so in the center it is likely that Jonny Evans and Phil Jones will defend.
Interestingly, "Man Utd" did not concede any goals away in the Champions League last season.