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Having suffered a thigh injury during training, forward Pablo Osvaldo will not be able to play for up to two months.
The team's newcomer has established himself in the starting lineup this season and is the top scorer, scoring seven goals. Barcelona's "Espanyol" received 17.5 million euros for him in the summer.
This is a painful blow to the Roma club, which recently loaned another forward, Marco Borriello, to Turin's "Juventus" team.