Striker Alexis Sanchez, who suffered a thigh injury, will not be able to play for approximately two weeks.
The Chile national team member suffered the injury during Saturday's match against Chichon "Sporting", although he only appeared on the field as a substitute.
"Alexis is only 22 years old, he needs to improve and understand what it means to play every three days," said coach Pep Guardiola. "He is a very important player for us, we will definitely miss him. This is another obstacle that we will have to overcome."
Sanchez will not be able to help the team in the return leg of the Champions League round of 16 match against Leverkusen "Bayer". On Wednesday, the Germans will arrive in Catalonia with the aim of avenging their 1-3 home defeat.
This season in the Spanish league, the striker scored eight goals in 15 matches.