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Madrid's "Real" and "Barcelona" clubs will face Basque team - the "Whites" will face San Sebastiano's "Real Sociedad", while "Barca" will play against Bilbao's "Athletic".
"Real" will play their match in their home arena, while "Barca" will have to travel to Bilbao's fortress.
In another pair, "Granada" will face "Valencia", while "Mirandes" will compete against "Villarreal".
The quarterfinals will be played on February 4-6.